SUP-ICU Publications

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Granholm A, Krag M, Marker S, Alhazzani W, Perner A, Møller MH. Predictors of gastrointestinal bleeding in adult ICU patients in the SUP-ICU trial. Acta Anaesthesiol Scand. 2021 Feb 26. doi: 10.1111/aas.13805. Online ahead of print. PMID: 33635540

Wang Y, Ge L, Ye Z, Siemieniuk RA, Reintam Blaser A, Wang X, Perner A, Møller MH, Alhazzani W, Cook D, Guyatt GH. Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: an updated systematic review and network meta-analysis of randomized trials. Intensive Care Med. 2020 Nov;46(11):1987-2000. doi: 10.1007/s00134-020-06209-w. Epub 2020 Aug 24. PMID: 32833040 Review.

Jensen MM, Marker S, Do HQ, Barbateskovic M, Perner A, Møller MH. Prophylactic acid suppressants in children in the intensive care unit: a systematic review with meta-analysis and trial sequential analysis. Acta Anaesthesiol Scand. 2021 Mar;65(3):292-301. doi: 10.1111/aas.13731. Epub 2020 Nov 22. PMID: 33147375 Review.


Granholm A, Marker S, Krag M, Zampieri FG, Thorsen-Meyer HC, Kaas-Hansen BS, van der Horst ICC, Lange T, Wetterslev J, Perner A, Møller MH. Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patient: a post hoc analysis of the SUP-ICU trial. Intensive Care Med. 2020 Apr;46(4):717-726

Marker S, Barbateskovic M, Perner A, Wetterslev J, Jakobsen JC, Krag M, Granholm A, Anthon CT, Møller MH. Prophylactic use of acid suppressants in adult acutely ill hospitalised patients: A systematic review with meta-analysis and trial sequential analysis. Acta Anaesthesiol Scand. 2020 Jul;64(6):714-728. doi: 10.1111/aas.13568. Epub 2020 Mar 5. PMID: 32060905 Review.

Schefold JC, Krag M, Marker S, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Lange T, Møller MH; the SUP-ICU investigators. Outcomes of Prophylactic Pantoprazole in Adult Intensive Care Unit Patients Receiving Dialysis: Results of a Randomized Trial. Am J Nephrol. 2019;50(4):312-319. doi: 10.1159/000502732. Epub 2019 Sep 3. PubMed PMID: 31480045.

Granholm A, Lange T, Anthon CT, Marker S, Krag M, Meyhoff TS, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Wetterslev J, Perner A, Møller MH. Time to onset of gastrointestinal bleeding in the SUP-ICU trial: A pre-planned substudy. Acta Anaesthesiol Scand. 2019 Nov;63(10):1346-1356. doi: 10.1111/aas.13459. Epub 2019 Sep 11. PubMed PMID: 31441031.

Granholm A, Marker S, Krag M, Zampieri FG, Thorsen-Meyer HC, Kaas-Hansen BS, van der Horst ICC, Lange T, Wetterslev J, Perner A, Møller MH. Heterogeneity of treatment effect of stress ulcer prophylaxis in ICU patients: A secondary analysis protocol. Acta Anaesthesiol Scand. 2019 Oct;63(9):1251-1256. doi:10.1111/aas.13432. Epub 2019 Jul 18. PubMed PMID: 31321771.

Marker S, Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Rasmussen BS, Elkmann T, Bestle M, Arenkiel B, Laake JH, Kamper MK, Lång M, Pawlowicz-Dworzanska MB, Karlsson S, Liisanantti J, Dey N, Knudsen H, Granholm A, Møller MH; SUP-ICU trial investigators. Pantoprazole in ICU patients at risk for gastrointestinal bleeding-1-year mortality in the SUP-ICU trial. Acta Anaesthesiol Scand. 2019 Oct;63(9):1184-1190. doi: 10.1111/aas.13436. Epub 2019 Jul 19. PubMed PMID: 31282567.

Granholm A, Perner A, Krag M, Marker S, Hjortrup PB, Haase N, Holst LB, Collet MO, Jensen AKG, Møller MH. External validation of the Simplified Mortality Score for the Intensive Care Unit (SMS-ICU). Acta Anaesthesiol Scand. 2019 Oct;63(9):1216-1224. doi: 10.1111/aas.13422. Epub 2019 Jul 4. PubMed PMID: 31273763.

Jensen MM, Marker S, Do HQ, Perner A, Møller MH. Stress ulcer prophylaxis in critically ill children: Protocol for a systematic review. Acta Anaesthesiol Scand. 2019 Aug;63(7):966-972. doi: 10.1111/aas.13361. Epub 2019 Mar 25. Review. PubMed PMID: 30907441.

Marker S, Perner A, Wetterslev J, Krag M, Lange T, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Møller MH; SUP-ICU investigators. Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial. Intensive Care Med. 2019 May;45(5):609-618. doi: 10.1007/s00134-019-05589-y. Epub 2019 Mar 12. PubMed PMID: 30863936.

Marker S, Perner A, Møller MH. Pantoprazole in Patients in the ICU. Reply. N Engl J Med. 2019 Mar 7;380(10):985. doi: 10.1056/NEJMc1900206. PubMed PMID: 30855753.

Barbateskovic M, Marker S, Granholm A, Anthon CT, Krag M, Jakobsen JC, Perner A, Wetterslev J, Møller MH. Stress ulcer prophylaxis with proton pump inhibitors or histamine-2 receptor antagonist in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Med 2019 Feb;45(2):143-158.

Krag M*, Marker S*, Perner A, Wetterslev J, Wise MP, Schefold JC, Keus F, Guttormsen AB, Bendel S, Borthwick M, Lange T, Rasmussen BS, Siegemund M, Bundgaard H, […] Møller MH. Pantoprazole in ICU patients at risk of a gastrointestinal bleeding. N Engl J Med 2018 Dec 6;379(23):2199-2208

Granholm A, Lange T, Anthon CT, Marker S, Krag M, Meyhoff TS, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Schefold JC, Wetterslev J, Perner A, Møller MH. Timing of onset of gastrointestinal bleeding in the ICU: protocol for a pre-planned observational study. Acta Anaesthesiol Scand 2018. In Press. [Accepted for publication Apr 28, 2018].

Barbateskovic M, Marker S, Jakobsen JC, Krag M, Granholm A, Anthon CA, Perner A, Wetterslev J, Møller MH. Stress ulcer prophylaxis in adult intensive care unit patients – a protocol for a systematic review. Acta Anaesthesiol Scand 2018;62(6):744-755

Schefold JC, Perner A, Lange T, Wetterslev J, Wise MP, Borthwick M, Bendel S, Keus F, Guttormsen AB, Marker S, Krag M, Møller MH. Effects of stress ulcer prophylaxis in adult ICU patients receiving renal replacement therapy (Sup-Icu RENal, SIREN): Study protocol for a pre-planned observational study. Trials. 2018 Jan 10;19(1):26

Marker S, Perner A, Wetterslev J, Barbateskovic M, Jakobsen JC, Krag M, Granholm A, Anthon CA, Møller MH. Stress ulcer prophylaxis versus placebo or no prophylaxis in adult hospitalised acutely ill patients – protocol for a systematic review with meta-analysis and trial sequential analysis. Syst Rev 2017;6(1):118

Krag M, Perner A, Wetterslev J, Lange T, Wise MP, Borthwick M, Bendel S, Pelosi P, Keus F, Guttormsen AB, Schefold JC, Meyhoff TS, Marker S, Møller MH. Stress ulcer prophylaxis in the intensive care unit trial: detailed statistical analysis plan. Acta Anaesthesiol Scand. 2017 Aug;61(7):859-868.

Marker S, Krag M, Møller MH. What’s new with stress ulcer prophylaxis in the ICU? Intensive Care Med. 2017 Aug;43(8):1132-1134.

Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, Pelosi P, Keus F, Guttormsen AB, Schefold JC, Møller MH; SUP-ICU investigators. Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial. Trials. 2016 Apr 19;17(1):205. doi: 10.1186/s13063-016-1331-3.

Krag M, Perner A, Møller MH. Stress ulcer prophylaxis in the intensive care unit. Curr Opin Crit Care. 2016 Apr;22(2):186-90.

Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU Collaborators. Stress ulcer prophylaxis in the intensive care unit: an international survey of 97 units in 11 countries. Acta Anaesthesiol Scand. 2015 May;59(5):576-85.

Krag M, Perner A, Wetterslev J, Wise MP, Borthwick M, Bendel S, McArthur C, Cook D, Nielsen N, Pelosi P, Keus F, Guttormsen AB, Moller AD, Møller MH; SUP-ICU co-authors. Prevalence and outcome of gastrointestinal bleeding and use of acid suppressants in acutely ill adult intensive care patients. Intensive Care Med. 2015 May;41(5):833-45.

Krag M, Perner A, Wetterslev J, Wise MP, Hylander Møller M. Stress ulcer prophylaxis versus placebo or no prophylaxis in critically ill patients. A systematic review of randomised clinical trials with meta-analysis and trial sequential analysis. Intensive Care Med. 2014 Jan;40(1):11-22.

Krag M, Perner A, Wetterslev J, Møller MH. Stress ulcer prophylaxis in the intensive care unit: is it indicated? A topical systematic review. Acta Anaesthesiol Scand. 2013 Aug;57(7):835-47.