CLASSIC trial eligibility

Inclusion criteria

All the following criteria must be fulfilled:

Ѵ  Aged 18 years or above

Ѵ  Admitted to the ICU or plan to be admitted to the ICU regardless of trial participation

Ѵ  Septic shock defined according to the Sepsis-3 criteria:

  • Suspected or confirmed site of infection or positive blood culture AND
  • Ongoing infusion of vasopressor/inotrope agent to maintain a mean arterial blood pressure of 65 mmHg or above AND
  • Lactate of 2 mmol/L or above in any plasma sample performed within the last 3-hours

Ѵ  Have received at least 1 L of IV fluid (crystalloids, colloids or blood products) in the last 24-hours prior to screening

Is the patient eligible? Go to screening