Eligibility

For the HOT-COVID trial

Inclusion criteria

Ѵ  Acute admission to the ICU, and

Ѵ  Aged 18 years or above, and

Ѵ Supplemental oxygen with a flow of at least 10 L oxygen per minutes in an open system including high-flow systems OR invasive or non-invasive mechanical ventilation/CPAP systems independent of the FiO₂ AND

Ѵ  Expected to receive supplemetal oxygen for at least 24 hours in the ICU AND

Ѵ  Having an arterial line for PaO₂ monitoring AND

Ѵ Confirmed SARS-CoV-2 infection in the time leading to or during current hospital admission