Compared the effects of stress ulcer prophylaxis with an acid suppressant (pantoprazole) versus placebo (saline) for critically ill patients admitted to the intensive care unit.


  • We observed no difference in infections, serious adverse events or mortality after 90 days, between participants treated with pantoprazole and those who received a placebo.
  • Among participants treated with pantoprazole, around 3% developed bleeding from the gastrointestinal tract compared with around 4% of participants treated with placebo.

These results have contributed significantly to our knowledge of prophylactic use of ulcer medication for intensive care patients. The results were published in the highly esteemed journal, New England Journal of Medicine, to see the full article click here.

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